An inverse relationship between serum macrophage inhibitory cytokine-1 levels and brain white matter integrity in community-dwelling older individuals

J Jiang; JN Trollor; DA Brown; JD Crawford; A Thalamuthu; E Smith; SN Breit; T Liu; H Brodaty; BT Baune; PS Sachdev; W Wen

Journal article

An inverse relationship between serum macrophage inhibitory cytokine-1 levels and brain white matter integrity in community-dwelling older individuals

J Jiang, JN Trollor, DA Brown, JD Crawford, A Thalamuthu, E Smith, SN Breit, T Liu, H Brodaty, BT Baune, PS Sachdev, W Wen

Psychoneuroendocrinology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2015

DOI: 10.1016/j.psyneuen.2015.07.610

Abstract

Macrophage inhibitory cytokine-1 (MIC-1/GDF15) is a marker of inflammation that has been associated with atherosclerosis. We have previously demonstrated its relationships with cognitive decline and cerebral gray matter volumes, suggesting its role as a biomarker of cognitive impairment. Considering that it is widely distributed in the brain, and both inflammation and vascular pathology impact on white matter (WM) integrity, we examined the relationship between MIC-1/GDF15 and measures of WM integrity, including WM volumes, mean fractional anisotropy (FA) values and WM hyperintensity (WMH) volumes in a community-dwelling non-demented sample of older individuals (. n=. 327, 70-90 years old). ..

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University of Melbourne Researchers

Bernhard Baune Author

Related Projects (1)

QUANTIYING CORTICAL THICKNESS AND WHITE MATTER HYPERINTENSITY VOLUMES AND DETERMINING THEIR RELATIONSHIP ON MRI IN AGEING BRAINS

Australia's population is ageing, with a significant projected increase in the number of people aged over 65 and 85. Mental health and qual..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

We thank the study participants and interviewers, as well the entire MAS team. We also thank Sophia Dean for her assistance with manuscript preparation. This research was supported by the National Health and Medical Research Council (NHMRC, https://www.nhmrc.gov.au/, NHMRC Program Grant ID 350833, NHMRC Project Grant ID 510175 and NHMRC Project Grant ID 510124), and the Australian Research Council (http://www.arc.gov.au/, DP0774213, DP0773584 and LP0669645).